My primary areas of research are the description, elucidation of the pathophysiology, of sleep disorders in aged humans, with a special focus on disturbed sleep in neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases. I have used a wide variety of research approaches, including observational, population-based studies, descriptive, laboratory-based research and randomized clinical trials involving both ambulatory and institutionalized aged populations. My interests also extend to sleep and sleep disorders as they relate to major geriatric syndromes, including nocturia, falls, fraility, incontinence, renal disease and agitation. My most recent funding from the National Institute of Neurologic Disease and Stroke (1R01 NS-050595) has focused on the non-motor symptoms of Parkinsonism, with particular emphasis on alterations in the sleep/wake cycle.
Rye DB, Bliwise DL, Parker K, Trotti LM, Saini P, Fairley J, Freeman A, Garcia PS, Owens MJ, Ritchie JC, Jenkins A (2012) Modulation of vigilance in the primary hypersomnias by endogenous enhancement of GABAA receptors. Science-Translational Medicine (in press).
Bliwise DL, Trotti LM, Juncos JJ, Factor SA, Freeman, Rye DB (2012). Daytime REM sleep in Parkinson’s disease. Parkinsonism and Related Disorders (Aug 29) [Epub ahead of print] PMID: 22939103
Fairley JA Georgoulas G, Mehta N, Gray A, Bliwise DL. (2012) Computer detection approaches forthe identification of phasic electromyographic (EMG) activity during human sleep. Biomedical Signal Processing and Control 7: 606-15. PMID: 23047598
Bliwise DL, Trotti LM, Yesavage JA, Rye DB (2012) Periodic leg movements in sleep in elderly patients with Parkinsonism and Alzheimer’s Disease. European Journal of Neurology 19: 918-23. PMID: 22340757
Bliwise DL, Trotti LM, Wilson AG, Greer SA, Wood-Siverio C, Juncos JJ, Factor S, Freedman A, Rye DB (2012) Daytime alertness in Parkinson’s disease: potentially dose-dependent, divergent effects by drug class. Movement Disorders 27: 1118-24. PMID: 22753297
Bliwise DL, Rye DB (2012) Respect for muscle: commentary on Frauscher et al. Normative EMG values during REM sleep for the diagnosis of REM sleep behavior disorder. SLEEP 35: 743-4. PMID: 22654188