Skip Navigation

Amanda A. H. Freeman, PhD

Instructor
Neurology

Phone: 404-712-7533

Fax: 404-727-6256

Biography

My interest in the field of sleep research began when I was in college. Working in a clinical sleep laboratory, it was clear to me that there were many unanswered questions about the neuroanatomical and molecular underpinnings of sleep regulation, particularly in pathological conditions.  Currently I am attempting to answer some of these questions by translating sleep disorders to the research laboratory where they can be explored at the neuroanatomical, physiological, molecular, and genetic level.  With a detailed understanding about the biological mechanisms of these disorders, I hope to contribute to the development of more focused diagnostic and treatment options for patients.  Specifically my research focuses on neurophysiological variances in primary hypersomnia and the development of a genetic model of Restless Legs Syndrome (RLS) in fruit flies.

Education & Training:

  • B.S. in Neuroscience, Baylor University, (1996)
  • Predoctoral Intramural Research Training fellowship, National Institutes of Health (1996-1998)
  • Ph.D., in Neuroscience, Emory University (2006)
  • Postdoctoral fellowships, Emory University (2006-2012)

Awards:

  • Curriculum Development Fellowship (HHMI), Emory University – 2011-2012
  • Training in Translational Research in Neurology Fellowship (NIH), Emory University – 2009-2011
  • Fellowship in Research and Science Teaching (FIRST) (NIH), Emory    University –  2006-2009
  • Dean’s Teaching Fellowship, Emory University – 2005-2006
  • Teacher-Scholar Fellowship (HHMI), Emory University – 2004-2005
  • Award for Excellence in Teaching, Emory University Graduate Division of Biological and Biomedical Sciences – 2000

Recent & Noteworthy Publications:

Freeman, A.A., Syed, S., and Sanyal, S. Modeling the genetic basis for human sleep disorders in Drosophila. Communicative & Integrative Biology. (In press)

Rye, D.B., Bliwise, D.L., Parker, K., Trotti, L.M., Saini, P., Fairley, J., Freeman, A., Garcia, P.S., Owens, M.J., Ritchie, J.C., and Jenkins, A. Modulation of Vigilance in the Primary Hypersomnias by Endogenous Enhancement of GABAA Receptors. Science Translational Medicine. (In press)

Freeman, A., Pranski, E., Miller, D., Betarbet, R., Bernhard, D., Jinnah, H., Rye, D. and Sanyal S. (2012) Sleep fragmentation and motor restlessness in a Drosophila model of restless legs syndrome. Current Biology 22(12):1142-8.  PMID: 22658601

Freeman A.*, Franciscovich, A.*, Bowers M., Sandstrom, D. and Sanyal S. (2010) NFAT regulates pre-synaptic development and activity-dependent plasticity in Drosophila. Molecular and Cellular Neuroscience 46(2):535-47. PMID:  21185939 (* denotes co-first authors) 

Freeman A.*, Bowers, M.*, Mortimer, A.V., Timmerman, C., Roux S., Ramaswami M., and Sanyal, S. (2010) A new model of activity-dependent pre-synaptic plasticity in Drosophila.  Brain Research 1326, 15-29. PMID: 20193670  (* denotes co-first authors)

Franciscovich, A.L., Vrailas Mortimer, A., Freeman, A., Gu, J., and Sanyal, S. (2008) Over-expression screen in Drosophila identifies neuronal roles of GSK-3β/shaggy as a regulator of AP-1 dependent developmental plasticity. Genetics 180(4), 2057-2071. PMID: 18832361

Felger, J.C., Alagbe, O., Hu, F., Mook, D., Freeman, A.A., Sanchez, M.M., Kalin, N.H., Ratti, E., Nemeroff, C.B., and Miller, A.H. (2007) Effects of interferon-alpha on rhesus monkeys: a nonhuman primate model of cytokine-induced depression.  Biological Psychiatry 62(11):1324-33.  PMID: 17678633

Daley, J., Turner, R., Freeman, A., Bliwise, D., and Rye, D. (2006).  Prolonged assessment of sleep and daytime sleepiness in unrestrained Macaca mulatta.  SLEEP 29(2), 221-231. PMID: 16494090

Pearl, P.L., LaFleur, B.J., Reigle, S.C., Rich, A.S., Freeman, A.A., McCutchen, C., Sato, S. (2002).  Sawtooth wave density analysis during REM sleep in normal volunteers.  Sleep Medicine 3(3), 255-8.  PMID: 14592215

Freeman, A., Ciliax, B., Bakay, R., Daley, J., Keating, G., Miller, D., Levey, A., and Rye, D. (2001).  An extensive dopaminergic thalamic innervation derives from nigrostriatal collaterals and degenerates in Parkinson’s Disease mode.  Annals of Neurology 50(3), 321-329.  PMID: 11558788