Assistant Professor / Staff Physician
Department of Anesthesiology, Atlanta VA Medical Center
As both a practicing neuroanesthesiologist and a scientist, I became interested in the pharmacology involved with sedation, sleep, coma, and anesthesia. For several years, I have been successfully collaborating with Drs. Rye and Jenkins on projects related to idiopathic hypersomnia and its potential mitigation with allosteric modulators of the GABA(A) receptor (e.g., drugs such as flumazenil). We have also successfully determined the baseline concentration of GABA in human CSF. My primary clinical interests are in neuroanesthesia and geriatric anesthesia, in particular aneurysm surgery, spine surgery, EEG and recovery from general anesthesia. I am confident that through our endeavors we will enhance what we know about the role of neuronal circuits in arousal from sleep and anesthesia.
Rye DB, Bliwise DL, Parker K, Trotti LM, Saini P, Fairley J, Freeman A, García PS, Owens MJ, Ritchie JC, Jenkins A (2012) Modulation of vigilance in the primary hypersomnias by endogenous enhancement of GABAA receptors. Science-Translational Medicine (in press).
Thaler A, Siry R, Cai L, García PS, Chen L, Liu R. Memory Loss, Alzheimer's Disease and General Anesthesia: A Preoperative Concern. Journal of Anesthesia and Clinical Research 2012 Jan; 3(2):192-196.
Liu R, García PS, Fleisher LA. Interest In Anesthesia As Reflected By Keyword Searches Using Common Search Engines Journal of Anesthesia and Clinical Research 2012 Jan; 3(1):187-195.
García PS, Alvarez A, Kambadar K, Nicholas G, Csete M. Elevated myostatin levels in patients with liver disease: A potential contributor to skeletal muscle wasting. Anesthesia and Analgesia 2010 Sep;111(3):707-9. PMID: 20686014
García PS, Gulati A, Levy JH. The role of thrombin and protease-activated receptors in pain mechanisms. Thrombosis and Haemostasis 2010 Apr 29;103(6). PMID: 20431855
García PS, Kolesky SE, Jenkins, A. General Anesthetic Actions on GABAA Receptors. Current Neuropharmacology 2010 Jan; 8(1). PMID: 20808541
García PS, Wright TM, Cunningham IR, Calabrese RL. Using a model to assess the role of the spatiotemporal pattern of inhibitory input and intrasegmental electrical coupling in the intersegmental and side-to-side coordination of motor neurons by the leech heartbeat central pattern generator. J Neurophysiol. 2008 Sep; 100(3):1354-71. PMID: 18579654
Norris BJ, Weaver AL, Wenning A, García PS, Calabrese RL. A central pattern generator producing alternative outputs: pattern, strength, and dynamics of premotor synaptic input to leech heart motor neurons. J Neurophysiol. 2007 Nov; 98(5):2992-3005. PMID:17804574
Norris BJ, Weaver AL, Wenning A, García PS, Calabrese RL. A central pattern generator producing alternative outputs: phase relations of leech heart motor neurons with respect to premotor synaptic input. J Neurophysiol. 2007 Nov; 98(5):2983-91. PMID: 17728387
Richardson JE, García PS, O'Toole KK, Derry JM, Bell SV, Jenkins A. A conserved tyrosine in the beta2 subunit M4 segment is a determinant of gamma-aminobutyric acid type A receptor sensitivity to propofol. Anesthesiology. 2007 Sep; 107(3):412-8. PMID: 17721243
Norris BJ, Weaver AL, Morris LG, Wenning A, García PA, Calabrese RL. A central pattern generator producing alternative outputs: temporal pattern of premotor activity. J Neurophysiol. 2006 Jul; 96(1):309-26. PMID: 16611849